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Research Paper | Medicine | India | Volume 13 Issue 12, December 2024 | Popularity: 4.9 / 10

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Clinical Significance of Platelet Indices (Mean Platelet Volume and Mean Platelet Volume-to-Lymphocyte Ratio) in Acute Coronary Syndrome: A Hospital-based Observational Study

Dr. Nirmal Kumar NK, Dr. Umesh Verma, Dr. Yatish, Dr. MN Khan

Abstract: Background: The role of platelet indices, such as mean platelet volume (MPV) and MPV-tolymphocyte ratio (MPVLR), in diagnosing, and predicting the severity, and fatality in acute coronary syndrome (ACS) has not been extensively studied, particularly in Indian patients. Therefore, the study aimed to investigate the clinical significance of MPV and MPVLR in ACS. Materials and methods: This hospital-based observational study was conducted in tertiary care hospital in India. It included 110 ACS cases and an equal number of age- and sex-matched controls with chest pain of noncardiac origin. The primary objective was to compare MPV and MPVLR in ACS patients and controls. Secondary objectives included examining the associations between MPV, MPVLR, and different ACS types, as well as their correlation with the global registry of acute coronary events (GRACE) risk score and inhospital major adverse cardiovascular events (MACE). Results: Higher MPV and MPVLR were observed in ACS cases compared to controls [(11.1 ? 1.1 fL; 10.6 ? 1.3 fL, p < 0.01), (7.63 ? 4.9 fL/mm3; 4.74 ? 1.6 fL/mm3, p < 0.01) respectively]. Significant associations were found between platelet indices (MPV, MPVLR) and various ACS types (p < 0.01). Both indices positively correlated with the severity of heart failure, GRACE score, and inhospital MACE (p < 0.01). MPVLR showed a positive correlation with the duration of hospital stay [(r: 0.21; p = 0.03), but MPV did not (r: 0.13; p = 0.17)]. The GRACE score demonstrated the highest discriminating capacity in predicting inhospital mortality compared to platelet indices. Additionally, MPV serves as a more effective prognostic marker than MPVLR in predicting inhospital mortality. Conclusion: Both MPV and MPVLR are higher in ACS than in healthy individuals. Therefore, both may be used as discriminating markers for differentiating cardiac and noncardiac chest pain when cardiac biomarkers are not available. Additionally, both have good sensitivity for predicting the severity of the disease, inhospital mortality, and MACE in ACS.

Keywords: MPV, MPVLR, ACS

Edition: Volume 13 Issue 12, December 2024

Pages: 961 - 965

DOI: https://www.doi.org/10.21275/MR241211205413

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