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Case Studies | Obstetrics and Gynecology | India | Volume 13 Issue 3, March 2024 | Popularity: 5.5 / 10

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Ovarian Stromal Hyperthecosis Mimicking PCOS: A Rare Case of Benign Abdomino - Pelvic Mass a Review

Dr. Tahseen Fatima, Dr. Sangeetha K, Dr. Rasisha R. S., Dr. Aishwarya R, Dr. Misbah Shawl, Dr. Sunanda Somu, Dr. Lynsel Hilda Texeira, Dr. Radha Nair, Dr. Asha Vasani, Dr. Farheen Madankhan Alizai, Dr. Trisha Shetty, Dr. Pooja B Acharya

Abstract: The purpose of this article is to highlight the diagnostic challenges and therapeutic outcomes of a rare case of ovarian stromal hyperthecosis presenting with PCOS features, aiming to contribute to the broader knowledge and management strategies for this condition. The term hyperthecosis refers to the presence of nests of lutenized theca cells in the ovarian stroma due to differentiation of the ovarian interstitial cells into steroidogenically active luteinized stromal cells producing excessive amounts of testosterone commonly presents in postmenopausal women with symptoms similar to those of polycystic ovarian syndrome. The disorder can result in metabolic abnormalities such as insulin resistance which can then lead to hyperinsulinemia. Hyperinsulinemia can result in an increased risk for Type 2 Diabetes Mellitus and cardiovascular disease. Acne and hirsutism secondary to high testosterone levels, which commonly represents. The study reports a rare case of ovarian stromal hyperthecosis presenting with features akin to Polycystic Ovarian Syndrome PCOS in a 44 - year - old pre - menopausal woman with Type 2 Diabetes Mellitus. Characterized by excessive testosterone production due to lutenized theca cells in the ovarian stroma, the condition mirrors PCOS symptoms, complicating diagnosis and treatment. The diagnosis of ovarian hyperthecosis was confirmed on histological examination. There is improvement in their hyperandrogenic symptoms, testosterone levels, and biochemical features of insulin resistance after surgical intervention. This case underscores the importance of differential diagnosis in hyperandrogenic conditions, particularly when testosterone levels are subdiagnostic. Post - surgical intervention showed significant improvement, highlighting the need for further research into the pathophysiology and diagnostic criteria of ovarian hyperthecosis.

Keywords: ovarian hyperthecosis, hyperandrogenism, pcos, metabolic syndrome, postmenopausal status, oophorectomy

Edition: Volume 13 Issue 3, March 2024

Pages: 51 - 54

DOI: https://www.doi.org/10.21275/MR24229112100

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