The Effect of Abelmoschus esculentus in Alloxan-Induced Diabetic Wistar Rat

Ben-Chioma A.E., Tamuno-Emine D.G., Dan D.B.

Abstract: The anti-hyperglycaemic activity of Abelmoschus esculentus fruits in alloxan-induced diabetic wistar rats was investigated. The animals were grouped into five (5), A, B, C, D, and E groups. Diabetic Mellitus was induced in groups B-E by single intravenous injection of alloxan, 65mg/kg body weight. Group A served as normal control (non-diabetic). Group C and D diabetic rats were administered with aqueous extracts and dried powdered form of Abelmoschus esculentus fruit respectively. Group E was administered with standard anti-diabetic drug [glibenclamide]. Treatment was for 14 days. Blood samples were taken and the fasting blood glucose levels measured at days 3, 7, and14. The aqueous and dried powdered form of Abelmoschus esculentus significantly decreased (p<0.05) blood glucose levels of the animals. The results support the therapeutic use of Abelmoschus esculentus as an anti diabetic plant.

Keywords: Anti-hyperglycaemic, Abelmoschus esculentus, Alloxan, Glibenclamide