Clinical Profile and Outcome in Patients with IgA Nephropathy

Dr. Dipti Trivedi, Dr. Manisha Panchal, Dr. Devang Patwari

Abstract: Aim To evaluate clinical profile and outcome in a patients with IgA nephropathy Methods989 patients with hematuria and proteinuria admitted in institute of kidney disease between jan 2002 to2004. Patients diagnosed to have IgA nephropathy included in study. The biopsy specimen examined for IF and histopathology. Patients were followed up for 6 to 15 month for outcome. Results Maximum number of patients between 11 to 30years (28 %). Male to female ratio is 2.11. Episodic hematuria (52 %), edema (80 %), and proteinuria (60 %) are common presenting complains. Biopsy shows MPGN (38 %) and Cresentric GN (24 %) commonly. Hypertension is the most common complication (80 %). Patients with cresentric glomerulonephritis deteriorated (24 %). Conclusion IgA is commonest primary glomerulonephritis. We can diagnose patients early by screening patients with hematuria and proteinuria. As there is no specific treatment available for IgA nephropathy meticulous control of blood pressure and judicious use of steroids and cytotoxic therapy may help to post pone dialysis and transplantation.

Keywords: IgA Nephropathy, Primary Glomerulonephritis, Cresentric Nephropathy, hematuria, proteinuria