The Amelioration of Carbon Tetracholride ? Induced Toxicities by Methanolic Extract of Buchholzia coriacea Leave in Male Albino Rat

AKINYEDE Kolajo.A, OYEWUSI Habeebat.A, OLOGUNDE Charles.A, ADENIYI Olayemi.A

Abstract: The study was designed to investigate potential ameliorative effect of methanolic leave extract of Buchholzia coriacea on carbon-tetrachloride (CCl4) - induced toxicities in male Albino rats. Thirty adult male Albino Rat were divided into five groups each comprising 6 animals, Group (I) the controls received only vehicles, olive oil (0.5 ml/kg bw) and DMSO, Group II (induction controls) received single dose of CCl4 (CCl4 + Olive oil in 11 ratio, 2 ml/kg bw, i. p, Group, IV and V received 200mg/kg bw, 400mg/kg methanolic extract of Buccholzia coriacea and 200mg/kg, Silymarin (50 mg/kg, o. p) as standard reference drug respectively after induction with a single dose of CCl4 for seven days. Evaluations were made for Lipid perioxidation and antioxidant activities, enzyme activities and some other biochemical parameters, haematology and pathology profile using standard methods. The methanolic leave extract of Buchholzia coriacea at 200mg/kg and 400mg/kg reduced the levels of AST and ALT, however, there was a significant (P

Keywords: Antioxidant activities, Buccholzia coriacea, Carbon tetrachloride, Lipid perioxidation and Toxicities

How to Cite?: AKINYEDE Kolajo.A, OYEWUSI Habeebat.A, OLOGUNDE Charles.A, ADENIYI Olayemi.A, "The Amelioration of Carbon Tetracholride ? Induced Toxicities by Methanolic Extract of Buchholzia coriacea Leave in Male Albino Rat", Volume 5 Issue 5, May 2016, International Journal of Science and Research (IJSR), Pages: 56-61, https://www.ijsr.net/getabstract.php?paperid=NOV163191, DOI: https://dx.doi.org/10.21275/NOV163191

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