Mechanism of Action of Hepatotoxicity Drugs

M. Meghana, K. Krishna

Abstract: Liver is the largest gland functioning as storage, manufacturing and biotransformation process. Due to increase exposure of drugs like anti-tubercular, anti-convulsants, NSAIDS, antibiotics etc. , causes liver damage like elevation in serum transamines, depletion of glutathione level, oxidative stress, formation of reactive metabolites by cytochrome p450 enzyme, depletion of adenosine triphosphate level, hypersensitivity reactions, sometimes the cause is not known (idiosyncratic toxicity) and hence many scientist and researchers have reported hepatoprotectants drugs.

Keywords: biotransformation, mechanism of hepatotoxicity drugs, hepatoprotectants drugs