Anti-Depressant Activity of Ethanolic Extract of Ghompherna Globosa in Swiss Albino Mice

S K. Jareena, Dr. D. Subbareddy, P. Koteeswara Reddy, M. Vamsi Krishna, V. Nikhitha, D. Abhilasha

Abstract: The antidepressant activity of Ethanolic extract of Gomphrena globosa (EEGG) in Swiss albino mice. Ethanolic extract of Gomphrena globosa (EEGG) Leaves was prepared by a continuous method using Soxhelt apparatures. The phytochemical screening followed by acute oral toxicity studies in mice. EEGG in doses of 100 and250 mg/kg body weight was administered to test groups 1 and 2 respectively. Imipramine hydrochloride 10 mg /kg body weight was administered to Standard group by oral route. The group second group received 100mg/kg, (p.o) of EEGG + 10 mg/kg (p.o) of Imipramine. Control group received normal saline 10mg/kg body weight. Anti depressant activity was identified by using modified forced swimming test (FSH) and Tail suspension test (TST). Period of immobility was observed in both the models which was indicative of anti depressant activity. Standard statistical methods were used to evaluate the results. The results showed significant dose dependent antidepressant effect of EEGG in swiss albino mice for both the models in all the test groups (Test group I, II, III, & IV). EEGG possess significant antidepressant activity. However, further investigations are required to determine its active constituents and molecular level of target mechanism of the extract for further use in humans.

Keywords: Antidepressant, imipramine, Gomphrenaglobose, Forced swimming test, Tail suspension test