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Research Paper | Anaesthesiology | India | Volume 11 Issue 11, November 2022 | Rating: 4.9 / 10

To Evaluate and Compare the Possible Analgesic Properties of Sevoflurane with Desflurane in Patients Undergoing Laparoscopic Cholecystectomies under Volatile Induction and Maintenance Anaesthesia (VIMA)

Dr. Gurleen Kaur | Dr. Mridul M Panditrao | Dr. Minnu M Panditrao | Dr. Nikhil Jaura

Abstract: Introduction: Sevoflurane, desflurane have been used in labour analgesia. Need more evidence to prove their analgesic properties, when used in VIMA. So, a randomized study single blinded comparative study was carried out. Method: 50 patients of either gender were randomly, equally allocated to 2 groups to be anaesthetized with sevoflurane or desflurane. Monitoring-routine multi parametric monitoring, depth of anaesthesia monitoring using Conox, qCON/qNOX kept between 40-60. Pain was scored using, VAS, before induction (T0), after extubation (T1), as shifted to Post Anaesthesia Care Unit (PACU) (T2), on demand of rescue analgesia/2 hours in PACU, whichever came first (T3). Rescue analgesia was administered before shifting to ward. Results: Demographically both the groups were similar. Haemodynamic parameters remained stable, suggesting, potentiation of fentanyl analgesia with appropriate depth of anaesthesia. VAS scores were consistently lower (1-3), at all time points. Recovery although far superior in desflurane group was also adequate even in sevoflurane group. In face of low VAS, rescue analgesia, had to be given pre-emptively before shifting to ward. Conclusion: Both IAAs have significant intraoperative and postoperative analgesic efficacy. Desflurane has rapid onset of analgesia, starting from time of induction. Amongst themselves the efficacy is similar.

Keywords: Volatile Induction Maintenance Anaesthesia (VIMA), Sevoflurane, Desflurane, Laparoscopic Cholecystectomy, VAS

Edition: Volume 11 Issue 11, November 2022,

Pages: 1168 - 1175