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Analysis Study Research Paper | Surgery | India | Volume 12 Issue 1, January 2023 | Rating: 5 / 10

Platelet Rich Plasma in the Treatment of Necrotizing Fasciitis

Satish Deshmukh | Aishwarya Tare | Niharika Saraf | Sanjeev Chowksey | Navin Wasnik

Abstract: Background: Necrotizing fasciitis is a severe bacterial soft tissue infection. It can quickly progress to life threatening sepsis. Once diagnosed, necrotizing fasciitis mandates an urgent surgical exploration for wound debridement. Platelet rich plasma is that portion of blood which has a platelet concentration significantly higher than that of baseline, containing growth factors that are of crucial importance in the mechanisms of wound healing and is an up - and - coming adjunct to standard wound care regimens. Methods: An observational study was carried out with 30 patients of necrotizing fasciitis who had undergone a fasciotomy, divided into two groups: a control group that received standard wound care and a study group that received wound care with PRP as an adjunct. Results: Percentage of change in wound dimensions (20%) vs (18.7%), incidence of postoperative wound discharge (13.3%) vs (16.67%), observation of unhealthy granulation tissue (40%) vs (60%), positive wound cultures after 6 weeks (6.67%) vs (10%), average time taken to proceed for grafting (47 days) vs (54.5 days) in case of PRP study group vs control group respectively. Conclusions: Patients treated with PRP as an adjunct in their wound management demonstrated faster healing and could be taken for a grafting procedure earlier than those who were managed with regular, betadine - based dressings only. Thus, PRP is a promising, cost effective and safe addition to wound management regimens, that can augment wound healing and even shorten the hospital stay of the patient.

Keywords: Necrotizing Fasciitis, Platelet Rich Plasma, Fasciotomy, Wound Care

Edition: Volume 12 Issue 1, January 2023,

Pages: 581 - 586