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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 12, December 2023 | Popularity: 4.9 / 10

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Formulation and Evaluation of Fexofenadine Nanoparticles Loaded in Gel

Ayesha Farhath Fatima, Ayesha Begum, Mariyam Yaseen

Abstract: Fexofenadine HCL belonging to class of Anti histaminic is a poorly soluble drug of BCS class II, administered orally as a tablet or a capsule exhibit stomach upset, cough, and fever. Consequently, the present ability heaved to develop nanoparticles to effortlessly consecrate fexofenadine HCL through topical sway to surmount issues. Fexofenadine HCL Nanoparticles through polymer is a tremendous approach used to explore the physiochemical plat of fexofenadine HCL. Nanoparticles of fexofenadine HCL were braced using ionic gelation methods using albumin and carbopol. The braced nanoparticles were guesstimated through solubility, dissolution, differential scanning colorimetry and Fourier transform infrared spectroscopy investigations. Different investigational approach of dissolution and solubility unveiled an increase in solubility among all formulations. The nanoparticles were prepared in 1:1ratio with albumin. Fexofenadine HCL Nanoparticles made known improvement in solubility and dissolution comparatively to authentic fexofenadine HCL. The forming nanoparticles endorsed by alterations in endothermic peaks of DSC and movement infra red spectrum of nanoparticles. Formulation and evaluation of fexofenadine HCL nanoparticles by Ionic gelation to enhance solubility was the major criterion of the present work. From these studies, it can be concluded that nanoparticles enhance solubility of fexofenadine HCL by using ionic gelation method.

Keywords: fexofenadine, Carbopol, nanoparticles, gel, ionic gelation method, topical gel

Edition: Volume 12 Issue 12, December 2023

Pages: 277 - 281

DOI: https://www.doi.org/10.21275/SR231202130925

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