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Analysis Study Research Paper | Pediatrics | India | Volume 12 Issue 4, April 2023 | Rating: 4.9 / 10

A Study on Clinical Correlation and Outcome of Dengue Fever with Hepatic Dysfunction in Children

Dr. Z. Havila Monalisa

Abstract: Objective: To study hepatic dysfunction in childhood dengue infection and to study clinical co - relation like severity, clinical features, and outcome. Methods: 70 Dengue seropositive patients were admitted during the study period and examined for hepatomegaly and jaundice and subjected to complete blood count, liver function tests, ultrasound abdomen, PT, APTT, HBsAg, HCV, widal and analysed. Results: All patients presented with fever, most commonly occurred in age group of 5 to 7years, hepatomegaly was the commonest clinical sign seen, thrombocytopenia was seen in 88% ofcases, Serum total bilirubin was raised in 10% of subjects with severe dengue infection. Serum SGOT was raised in 72.8 % of patients with dengue. When compared between the groups, rise in SGOT occurred in 58.6%, 78.8 % and 100% of patients with dengue without warning signs, with warning signs and in severe dengue respectively. SGPT was raised in 58% of patients with dengue infection. When compared between the groups, rise in SGPT occurred in 44.8%, 66.6% and 75% of patients with dengue without warning signs, with warning signs and in severe dengue respectively. Prothrombintime was raised in 11% of patients with dengue infection. When compared between the groups, rise in PT occurred in 9% with warning signs and 62.5% in severe dengue. Activated Partial Thromboplastin Time was raised in 11% of patients with dengue infection. When compared between the groups, rise in APTT occurred in 9% of patients with warning signs and 62.5% in severe dengue. Serumtotal protein was reduced in 12% of patients with dengue infection. When compared between the groups fall in serum protein occurred in 15% with warning signs and 50% in severe dengue. Serum Albumin was reduced in 3% of patients with dengue infection. In our study 2 cases suffering from severe dengue expired, in which the enzyme levels were highly elevated. Conclusion: Significant rise of liver enzymes helps in recognition of severe forms of dengue infection. As hepatic dysfunction in Dengue is transient and reversible, early identification of the same should help to reduce life threatening complications. Serial liver function tests can help in early detection of fulminant hepatic failure. This can help to reduce the morbidity and mortality.

Keywords: Hepatic dysfunction, Dengue infection, Prothrombintime

Edition: Volume 12 Issue 4, April 2023,

Pages: 991 - 994