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Analysis Study Research Paper | Medicine | India | Volume 12 Issue 5, May 2023 | Rating: 4.6 / 10
Correlation of Sputum and Peripheral Eosinophil Count in Assessing the Clinical Severity in Bronchial Asthma
Dr. K. Arun Vishnu [6] | Dr. Trinath Dash [5] | Dr. Athul. C. Angaj [4] | Dr. Priya Pankaj [3] | Dr. Sarvendra Vikram Singh [3] | Dr. T. S. Swetha [2] | Dr. Aravindan K [3]
Abstract: Asthma, a chronic airways disease, is often related to airway or blood eosinophilia. Importantly, asthmatics with significant eosinophilia are at higher risk for more severe disease. The evidence including clinical studies have demonstrated a causal role for eosinophils in asthma pathogenesis including airway hyper - reactivity, elevated mucus production and airway remodelling. The eosinophilic phenotype of asthma is related to type 2 cytokines such as interleukin (IL) - 4, IL5, and IL - 13. Corticosteroid (CS) is a key anti - inflammatory agent to control eosinophilic inflammation, and biologics targeting type 2 inflammation are effective in SA with high total eosinophil count (TEC). Recent studies have proposed a role for eosinophils in humoral immunity as an important source of pro - survival factors for long - lived plasma cells in the bone marrow. Thus, treatments that specifically target eosinophils are likely to be effective in controlling a number of important and prevalent diseases like asthma. The increasing incidence of eosinophil - associated disorders, as asthma, in high income and low income countries highlights the important and expanding need for eosinophil - targeted therapies. An emerging priority to standardize biological markers related to the eosinophils in clinical research. There was scarcity of the published literature to find the relationship between the peripheral eosinophils counts and severity of asthma. Hence, the present study was conducted to find the correlation between the serum and peripheral eosinophils count in the assessment of clinical severity of asthma.
Keywords: asthma exacerbation, sputum eosinophil count, allergy, eosinophilic inflammation, eosinophil targeted therapy
Edition: Volume 12 Issue 5, May 2023,
Pages: 535 - 544