Warfarin Induced Skin Necrosis - A Case Report

Dr. Payel Chakraborty, Prof Dr. Supreeti Biswas Mondal, Dr. Joydip Das, Dr. Koustuv Chowdhury

Abstract: Warfarin induced skin necrosis (WISN) is an uncommon catastrophic complication of oral anticoagulant therapy. A 30 years old lady had a history of venographically proven puerperal deep vein thrombosis developed a ?painful bruise? on her left leg, thigh. The skin at the center of the area was supposed to break after necrosis occurred over the following 48 hours. Warfarin was discontinued. This case was diagnosed as an adverse drug reaction of warfarin causing skin necrosis. INR level should be monitored before starting treatment with warfarin and if any risk factor is stated alternative therapy for anticoagulation should be given.

Keywords: Warfarin, Skin necrosis, Bruise