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Research Paper | Medical Science | Pakistan | Volume 12 Issue 9, September 2023 | Popularity: 4.6 / 10

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Influence of Anti PD-1 Therapy on Cancer Metastasis by Modulation of the Cancer Micro Environment

Nabiha Rahman

Abstract: One of the major factors that make cancer particularly lethal is its ability to metastasize. Cancer, localised at primary site, is generally associated with good prognosis, however, its escape from the confines of primary organ and onto distant organs is largely untreatable (Zubair & Ahmad, 2017) . Major advances in cancer immunotherapy have dramatically expanded the potential to manipulate immune cells in cancer patients with metastatic disease to counteract cancer spread and extend patient lifespan. One of the most successful types of immunotherapy is the immune checkpoint inhibitors, such as anti-CTLA-4 and anti-PD-1, that keep antitumor T cells active. However, not every patient with metastatic disease benefits from this class of drugs and patients often develop resistance to these therapies over time (Edwards et al., 2020). This report focuses on the impact of anti PD-1 therapy on individual immune cells in order to determine its effect on the cancer microenvironment and the rate of metastasis. There are multiple different immune cells having various contributions towards metastatic growth and each of these cell types respond differently to Anti PD-1 blockade. It is therefore essential to understand immune composition and the driving factors of metastasis on a patent-specific level before recommending Anti PD-1 therapy. This will lead to a maximised potential of a positive clinical outcome, reducing the risk of cancer remission and metastasis.

Keywords: cancer, metastasis, immunotherapy, immune cells, anti PD-1 therapy

Edition: Volume 12 Issue 9, September 2023

Pages: 1496 - 1500

DOI: https://www.doi.org/10.21275/SR23918090707

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