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Research Paper | Radiotherapy & Oncology | India | Volume 13 Issue 10, October 2024 | Popularity: 5.7 / 10
Comparative Analysis of DysphagiaOptimized IMRT vs Standard IMRT in Oral Cavity Cancer Treatment: A Single - Center Study
Ramyavardhani Mamidala, Prathipati Navyasri, Kotlapati Sudhakar, Jyothi Jonnadula, Prattipati Srinivas, Thota Ajay
Abstract: Objective: This study investigates the efficacy of Dysphagia Optimized Intensity Modulated Radiotherapy (Do - IMRT) compared to Standard Intensity Modulated Radiotherapy (S - IMRT) in managing dysphagia and overall treatment efficacy among patients with oral cavity cancers treated at the Department of Radiation Oncology, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad. Methods: We enrolled 300 patients diagnosed with oral cavity cancers from July 2022 to July 2024, randomly assigning them to either the Do - IMRT group (n=150) or the S - IMRT group (n=150). Dysphagia severity was assessed using the Dysphagia Severity Rating Scale (DSRS) at baseline, during treatment, and at a 6 - month follow - up. Treatment outcomes, including overall survival rates and treatment - related toxicities, were analyzed. Results: Patients treated with Do - IMRT demonstrated significantly reduced dysphagia, as evidenced by lower DSRS scores during treatment and at 6 months post - treatment (p < 0.01) compared to the S - IMRT group. Overall survival rates were similar (DoIMRT: 78%, S - IMRT: 75%). Treatment - related toxicities were reduced in the Do - IMRT group (15% vs.30%, p < 0.05), indicating better tolerability. Conclusion: Do - IMRT significantly improves dysphagia outcomes without compromising overall survival in patients with oral cavity cancers. This approach offers potential as a superior treatment strategy for dysphagia management in this population.
Keywords: Dysphagia, Optimized Intensity Modulated Radiotherapy (Do - IMRT), Standard Intensity Modulated Radiotherapy (S - IMRT), Oral Cavity Cancer, Single - Center Study
Edition: Volume 13 Issue 10, October 2024
Pages: 644 - 647
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