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Research Paper | Health Sciences | India | Volume 13 Issue 1, January 2024 | Rating: 5.8 / 10

Enhancing Breast Lump Diagnostics: A Comparative Study of Histopathological and Cytology

Dr. Sapna Singla | Dr. Rudrax Bhatt | Dr. Kanwar Singh Goel | Dr. Alisha Chhibber | Dr. Abhishek Yadav | Dr. Milan Patel

Abstract: Introduction: The increasing incidence of breast lumps cases represents a significant health challenges, necessitating. The integration of multiple diagnostic modalities, including histopathological and cytological techniques, is imperative. Correlating histopathological findings with cytological evaluation can significantly enhance the accuracy of preoperative diagnosis and contribute to the development of evidence-based guidelines for integrating cytological evaluation into the diagnostic algorithm for breast lumps. Methods: In a prospective observational study at a tertiary care teaching hospital, female patients aged 18 years and above with palpable breast lumps were enrolled according to the inclusion criteria. Data on demographics and clinical history were collected. Histopathological and cytological evaluations were conducted, assessing concordance, with statistical analysis revealing sensitivity, specificity, PPV, and NPV of cytological evaluation. Ethical considerations, including informed consent and confidentiality, were obtained. Results: In the cytological evaluation of 290 breast lump cases, benign cases constituted the majority, accounting for 68%, followed by malignant cases at 27.5%. Out of 290 patients, 75 underwent histopathological examination. Among these, 30 cases were diagnosed as benign, while 45 were identified as malignant. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the present study were 80.12%, 95.62%, 97.2%, 70.12%, and 84.52% respectively. Among cases, 84% exhibit concordance, while 16% show discordance, suggesting a strong association between the two diagnostic methods in the study. Conclusion: The demographic characteristics, cytological and histopathological findings, along with the correlation analysis, provide a comprehensive understanding of the diagnostic process of breast lump cases. High concordance and favorable statistics validate diagnostic test reliability; addressing discordance improves breast lump diagnosis accuracy.

Keywords: Breast lumps, Histopathology, Cytology, Diagnostic correlation

Edition: Volume 13 Issue 1, January 2024,

Pages: 488 - 493