Parry - Romberg Syndrome: A Case Study of Hemifacial Atrophy and Treatment Outcomes

Dr. Sourab S Hegde, Dr. Rajesh L Pathi, Dr. Kishor C

Abstract: Parry - Romberg Syndrome (PRS) is a rare neurocutaneous disorder characterized by progressive hemifacial atrophy, predominantly affecting the skin, subcutaneous tissue, muscle, and bone. This case study discusses a 19 - year - old female presenting with worsening facial asymmetry over three years. Clinical findings included hemifacial atrophy on the right side, hyperpigmented patches on the forehead and periorbital area, and alopecia of the right eyebrows, with unremarkable neurological and ocular assessments. Diagnosis was confirmed through clinical and histopathological evaluation. The patient was treated with methotrexate, which showed mild improvement in alopecia and skin lesions. PRS treatment often involves a multidisciplinary approach, including medical and surgical interventions, to address functional impairments and enhance quality of life. This case underscores the importance of early diagnosis and a comprehensive management strategy in improving patient outcomes.

Keywords: Parry - Romberg syndrome, hemifacial atrophy, case study, methotrexate treatment, multidisciplinary care