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Research Paper | Neuroscience | India | Volume 13 Issue 12, December 2024 | Popularity: 5.6 / 10
Stroke in the Patients with Ischemic and Nonischemic Dilated Cardiomyopathy
Dheeraj Kumar Soni, Deepika Sagar
Abstract: Objectives: Patients with dilated cardiomyopathy (DCM) may have a high incidence of clinically asymptomatic or symptomatic stroke. Prevalence of Stroke and its risk factors may be different between ischemic and nonischemic DCM. The purpose of this study was to evaluate the prevalence and related parameters of silent stroke in patients with ischemic and nonischemic DCM. Methods: 72 Patients with ischemic and nonischemic DCM (53 male, 19 females, aged 62 ? 12 years) were included in the study. Etiology of DCM was ischemic in 45 and nonischemic in 27 patients. Fifty-five age- and gender-matched healthy volunteers served as a control group for comparison of stroke prevalence. Results: Prevalence of stroke was 38%, 28%, and 3.6% in ischemic, nonischemic DCM, and control group, respectively (ischemic DCM vs control group, p < 0.001, nonischemic DCM vs control group, p = 002). In patients with nonischemic DCM, the mean age of the subjects with SCI was significantly higher than that of subjects without lesions (68 ? 5 years vs 52 ? 13, p < 0.001), whereas in ischemic DCM NHYA Functional Class was statistically higher in patients with SCI than without SCI (p = 0.03). In both groups, patients with SCI had lower systolic functions than patients with normal MRI findings. In multivariable logistic regression analysis, restrictive type of diastolic filling pattern was found as an independent factor for SCI occurrence on the whole patient population (OR: 16.5, 95% CI: 4.4?61.8, p < 0.001). Conclusion: Stroke is common in patients with both ischemic and nonischemic DCM. In univariate analysis, both groups have similar systolic and diastolic characteristics for the occurrence of SCI. Restrictive diastolic filling pattern is found to be an independent risk factor in the occurrence of SCI for the whole patient population in logistic regression analysis.
Keywords: ischemic dilated cardiomyopathy, nonischemic dilated cardiomyopathy, silent cerebral infarction, restrictive diastolic filling, age, functional status
Edition: Volume 13 Issue 12, December 2024
Pages: 1686 - 1691
DOI: https://www.doi.org/10.21275/SR241226211049
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