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Review Papers | Pharmaceutical Science | India | Volume 13 Issue 3, March 2024 | Rating: 4.9 / 10
Advancements in Tuberculosis Treatment: From Epidemiology to Innovative Therapies
Abhay Thakur
Abstract: This review provides a comprehensive overview of current advancements in the treatment of tuberculosis (TB), covering various aspects from epidemiology to novel therapeutic approaches beginning after a brief overview of TB including a global impact and historical context, the review explores the epidemiology of anti-TB medications and the emergence of antibiotic resistance mechanisms in Mycobacterium tuberculosis. It discusses ongoing clinical trials for anti-TB drugs and emphasises the critical need for innovative therapeutic approaches to stop the spread of drug-resistant tuberculosis strains. The review examines recent developments in overcoming M. tuberculosis antibiotic resistance, focusing on innovative treatments designed to circumvent resistance mechanisms. It explores the potential of nano delivery systems for enhancing TB treatment efficacy, discussing the promises and challenges associated with these novel approaches. The review delves into the various approaches and challenges in treating M. tuberculosis, shedding light on the complexities of TB therapy and the importance of multidisciplinary strategies. It specifically investigates dendrimer-based formulations in drug delivery, with a focus on Poly (amidoamine) (PAMAM) dendrimers as potential agents for treating M. tuberculosis. Finally, it explores the antibacterial properties of dendrimers and their potential application in combating TB infections. Given the circumstances, this article offers a thorough summary of the state of TB treatment today, highlighting the need for innovative approaches to address the challenges posed by drug resistance and the complex nature of TB therapy.
Keywords: Mycobacterium Tuberculosis, Novel Treatment, Dendrimer-Based Formulations, Anti -Tb Drug under trials
Edition: Volume 13 Issue 3, March 2024,
Pages: 206 - 216