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Research Paper | Animal Science | India | Volume 13 Issue 6, June 2024 | Rating: 4.3 / 10
Sodium Fluoride (NaF) Induce Biochemical and Histological Alternation in Liver and Kidney of Fresh Water Fish Cirrhinus Mrigala
Abstract: A wide range of environmental and genetic factors cause fish to respond differently to given levels of fluorides, but they do display characteristic fluoride intoxication signs. Some of the variation can also be explained by postulating a sodiuum - fluoride excretion mechanism over the epithelial tissues. Such a mechanism would explain variations in toxicity correlated with different concentrations and the survival of natural populations of fish at sodium fluoride concentrations which are lethal under laboratory conditions. Ever increasing water pollution level, especially sodium fluoride (NaF), in natural and inland freshwater reservoir condition has made significant biochemical and histological changes in the fishes. In view of this, the investigations on effects of acute and chronic concentration of sodium fluoride to fish Cirrhinus mrigala have been carried out. The biochemical changes in glycogen, protein and lipid content of selected tissues like liver and kidney were examined. The histological alteration was studied in liver and kidney. The study revealed a highest loss of glycogen, protein and lipid percentage in selected organ and results of the light microscopic studies showed that the histological changes were evident in the liver and kidney of fish exposed to LC0 (910ppm) and LC50 (935ppm) concentration of sodium fluoride. Liver showed clear congestion, infiltration of mononuclear lymphocyte around the vena centralis as compared to control in liver. In kidney tubular epithelium showed necrotic changes characterized by karyorrhexis and karyolysis at the nuclei of the cells. Lumens of the tubules were found invariably dilated.
Keywords: Sodium fluoride, biochemical, histological, body tissue liver and kidney
Edition: Volume 13 Issue 6, June 2024,
Pages: 754 - 758