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Case Studies | Medicine | India | Volume 13 Issue 6, June 2024 | Rating: 5.7 / 10
Pernicious Anaemia as a Cause of Ischemic Hepatopathy
Dr. Pal Patel | Dr. Rajkumar Patel
Abstract: Pernicious anemia, a condition characterized by the deficiency of vitamin B12, can lead to significant systemic complications due to its impact on red blood cell production and neurological functions. One of the less commonly discussed but severe complications of pernicious anemia is ischemic hepatopathy, also known as shock liver. Ischemic hepatopathy occurs due to the sudden decrease in blood flow to the liver, often precipitated by cardiovascular instability. This condition can manifest in patients with pernicious anemia due to the increased risk of cardiovascular events and circulatory insufficiency associated with severe anemia. This abstract explores the pathophysiological mechanisms linking pernicious anemia to ischemic hepatopathy, including the roles of hypoxemia, microvascular dysfunction, and cardiac output reduction. Early diagnosis and management of pernicious anemia are critical in preventing the progression to ischemic hepatopathy. Clinical awareness of this potential complication is essential for timely intervention and improving patient outcomes.
Keywords: Pernicious Anemia, Ischemic Hepatopathy, Vitamin B12 deficiency, Disseminated intravascular coagulation
Edition: Volume 13 Issue 6, June 2024,
Pages: 1868 - 1870