Selective Electrochemical Determination of Desipramine Using a Lipid Modified Carbon Paste Electrode

M. Khodari

Abstract: Carbon paste electrodes have been modified with some lipids for the sensitive and selective detection of the antidepressant (Desipramine). Voltammetric experimental conditions were optimized taking into account the importance of quantifying desipramine in the complex media and in the pharmaceutical formulations. The sensor (Lauric acid modified carbon paste electrode) responds to desipramine giving a cathodic current (at +0.88 V vs. Ag/AgCl electrode and pH 9). The response was characterized with respect to preconcentration potential, accumulation time, paste composition, possible interferences and other variables. A linear relationship between peak response and desipramine concentration over the range from 1 x10-7 to 1 x10-6 M. with standarad deviation of 5.5 %. A detection limit of 3.3 x10-10 M was obtained under the optimum conditions The method has been applied to the determination of desipramine in serum and urine samples

Keywords: Desipramine, Linear sweep voltammetry, carbon paste electrode, Fatty acids, modifiers