Synthesis and Characterization of Some Coumarin Derivatives

Pravin Chowdhary, Vrushali Patil, Ashish Asrondkar, Anil Bobade, Abhay Chowdhary

Abstract: A series of coumarin derivatives were synthesized. The present study reveals the synthesis of coumarin derivative in which 4-hydroxycoumarin was reacted with chloroethylacetate in preseance of K2CO3 to form an intermediate which was further treated with hydrazine hydrate to form hydrazino derivative of coumarin and finally the intermediate is condensed by substituted isothiocynate derivatives to form final compound, the synthesized compounds were then Characterized by using FT-IR, 1H-NMR and Mass spectrophotometer, All the compounds were screened for their anti-microbial activity. It was found that the derivatives showed moderate activity as compared to standard

Keywords: Coumarin, anti-microbial activity