Toxicity of Organophosphate Insecticide on Relative Body and Liver Weights of Mice

Santosh Pawar

Abstract: The present study deals with the changes in relative body and liver weights of mice treated with different doses of cythion (Organophosphate insecticide) ranging from 10, 50, 100 and 500mg/kg/day diet. Cythion concentration of 500 mg/kg/day diet at 90 days produced a significant increased in body weight as compared to untreated mice. Liver weight also showed dramatically more pronounced after 14th days till 90 days of treatment period as compared to control mice. An increased in the weight of liver and the concomitant increased in the activities of detoxifying enzymes suggest that the activities of the detoxifying enzymes on administration of cythion that may increased the weight of liver till 90 days of intoxication.

Keywords: Cythion, liver, body weight