New Laboratory Biomarkers for Early Diagnosis of Preeclampsia

Albana Daka, Anyla Bulo

Abstract: The aim of the study was to examine whether increased serum sFlt1 levels are related to development of PE. Subjects were recruited from the Obstetrics and Gynecology Department at American Hospital in Tirana, Albania between January 2012 and December 2014. The study subjects included 95 women who subsequently developed preeclampsia and 140 women with normal singleton pregnancies who were matched for maternal age, and gestational age. sFlt-1 levels were significantly higher in the preeclamptic women, median-interquartile range 4011.2 (157.7) than in normal controls 679.2 (140.1) (p<0.001), while the PlGF levels were significantly lower, 402 (14) as compared to controls 1128.6 (62.5) (p<0.001) (fig.2). In preeclamptic women, sFlt-1 levels were negatively correlated with the PlGF levels (r=-0.25, p=0.04). The predictive accuracy of preeclampsia was higher as denoted by greater AUC (0.982). In future these biomarkers will be the first signals for preeclampsia and help prevent its severe forms.

Keywords: preeclampsia, sFlt-1, PlGF, gestational age, hypertension